1. Introduction to Biology

Biology is the study of life—a four-letter word that connects you to 4 billion years worth of family tree. The word “life” can be tricky to define, but a shared set of characteristics helps biologists identify living things. In this episode of Crash Course Biology, you’ll learn how all of life is connected, and why studying biology can help us better understand ourselves and our relationship to all living things.

2. The Scientific Method

Science offers a way of discovering and understanding the world around us, driven by questions and tested with evidence. And it’s a twisty-turny team effort— you won’t find many lone geniuses out there, or straight lines from hypothesis to conclusion. In this episode of Crash Course Biology, we’ll talk about the big picture of how scientific progress is made, from peer review to mathematical models, with some exploding eggs along the way.

3. What Biologists Do

A biologist’s natural habitat is anywhere questions about life are being asked—whether the subject is a nematode or a narwhal, a single cell, or a whole ecosystem. In this episode of Crash Course Biology, we’re flipping the microscope around to show how biologists’ work goes down. Along the way, we’ll learn why zebrafish and fruit flies are some of biology’s next top models.

4. How Life is Organized

Here on Earth, life is dizzyingly diverse—but it’s also surprisingly organized. A sense of order structures life and its processes, from the tiniest cell to the total sum of every living thing. In this episode of Crash Course Biology, we’ll uncover the levels of biological organization, discover soil’s superpowers, and find out why the biosphere is kind of like a really, really long train.

5. Why Did All These Elephants Die? (Intro to Ecology)

Ecology is the study of the interactions of living things with each other and their environment. It’s a field that not only lets us explore the interconnections between living things, but also how our environment affects us, and how we influence it in turn. In this episode of Crash Course Biology, we’ll get an overview of the field of ecology, see how matter and energy are conserved and transferred through ecosystems, and follow an ecological mystery surrounding the deaths of hundreds of elephants in Botswana, Africa.

6. How Species Make and Break Friendships (Community Ecology)

Community ecology is the study of interactions between different species of living things, and lets ecologists examine the effects of predator-prey relationships, parasites, and mutually beneficial interactions. In this episode of Crash Course Biology, we’ll examine the myriad interspecies interactions with examples, see how keystone species impact their environment and explore how communities rebuild when they are disrupted, through the lens of the 1980 eruption of Mount St. Helens.

7. How Did We Save The Bald Eagle? (Population Ecology)

When the Bald Eagle population started to decline in the mid-20th century, scientists began to ask why. Population ecology, the study of organisms of the same species, played a big role in answering that question. In this episode of Crash Course Biology, we’ll take a look at the methods population ecologists use to study a population and the types of data they collect. We’ll also find out how scientists helped bring the Bald Eagle back from the brink.

8. What Is Climate Change?

Life on Earth has weathered boiling-hot oceans and volcanic-ash-darkened skies—but that’s nothing like the climate change we’re experiencing now. In this episode of Crash Course Biology, we’ll talk about the greenhouse effect, learn why our climate is like a tangled pair of headphones, and discover that we’ve understood the science behind climate change for much longer than you might think.

9. The Effects of Climate Change

Climate change shakes up all of Earth’s systems, including the living ones. In this episode of Crash Course Biology, we’ll see how climate change’s effects rattle the entire chain of life. Changes felt in one population ripple out to affect entire communities and ecosystems—whether they’re composed of pine trees, puffins, or people.

10. How Do We Keep Life's Jenga Tower From Toppling? (Conservation Biology)

Some scientists believe we are in the middle of Earth’s sixth mass extinction: a big, precarious game of Jenga that involves every ecosystem on the planet. In this episode of Crash Course Biology, we’ll see how conservation biology aims to restore habitat and preserve biodiversity. Along the way, we’ll see how environmental damage impacts human communities, and learn about wolves’ return to Yellowstone National Park.

11. What a weirdly long giraffe nerve can teach us about evolution

From a single-celled common ancestor, evolution has brought us all of Life’s Greatest Hits — including butterflies, beetles, bacteria, and human beings. In this episode of Crash Course Biology, we’ll learn how evolution explains life’s unity and diversity. Along the way, we’ll explore the fishy origins of a giraffe’s neck, and find out what a cat’s paw and your own arm have in common.

12. Microevolution: What's An Allele Got To Do With It?

Whether we’re talking about tigers, trees, or tarantulas, evolution happens at the level of the population. In this episode of Crash Course Biology, we’ll find out how natural selection, gene flow, genetic drift, and other processes drive changes in populations. We’ll learn about the Hardy-Weinberg equation, how your alleles make you uniquely you, and how some tigers changed their stripes.

13. Natural Selection: Life's Way of Stayin' Alive

There are lots of ways that evolution happens, and natural selection is just one of them. In this episode of Crash Course Biology, we’ll find out how this process works and shapes traits in all living things —from ginkgo trees to howler monkeys. We’ll also learn how extra-grippy toes help some lizards survive hurricanes.

14. Why do we have different skin colors? (Population Genetics)

In this episode of Crash Course Biology, we’ll learn about the ways population genetics reveals how groups of living things evolve—by comparing genetic similarities and differences. We’ll discover the most genetically diverse species of all (hint: it’s not us), find out why “race” isn’t the biologically valid category we’ve made it out to be, and learn there’s much more in our DNA that we share than that sets us apart.

15. Where Do Species Come From? (Speciation)

How can you tell two species apart? It’s not always simple. In this episode of Crash Course Biology, we’ll learn about speciation—a process that can happen over millions of years, or within a single generation. Along the way, we’ll discover how a single species can split into two and how a reptile from New Zealand continues to stump scientists.

16. How did life begin? (Evolutionary History)

Humans may have been around for a long time, but life has existed for way longer. In this episode of Crash Course Biology, we’ll journey through deep time to uncover the history of life on Earth. We’ll explore the big, game-changing leaps where life diversified, changed, and just plain persisted.

17. How We're All Related (Phylogeny)

Crocodiles, and birds, and dinosaurs—oh my! While classifying organisms is nothing new, phylogeny— or, grouping organisms by their evolutionary relationships—is helping us see life in a whole new light. In this episode of Crash Course Biology, we’ll learn why this kingdom-phylum stuff is going out of style and why phylogenetic trees are in.

18. Humans Develop Butt First (and other insights from the Tree of Life)

Everywhere you look on Earth, you’ll find wonderful and diverse living things, from tiny tardigrades to soaring sequoias. And incredibly, everything alive today, and everything that’s ever lived, is related. In this episode of Crash Course Biology, we reveal how the evolutionary relationships between living things define their place on a single, great Tree of Life, and we learn what that tree can tell us about our own place among the planet’s biodiversity.

19. Humans Didn't Evolve From Chimps (Human Evolution)

What’s a human? And how did we become humans, anyway? In this episode of Crash Course Biology, we’ll meet some of our closest relatives and trace how we evolved into the brainy, inventive, complex species we are today.

20. What is Life Made of? (Carbon & Biological Molecules)

Despite the diverse appearance and characteristics of organisms on Earth, the chemicals that make up living things are remarkably similar, often identical. In this episode of Crash Course Biology, we’ll look at the building blocks of the four major classes of biomolecules, how those join up to form macromolecules, and how a team of six atoms forms the vast majority of living matter.

21. A Love Letter to H2O: Water & pH

This is a love letter to water, life’s solvent, and one of the most wonderful molecules around. In this episode of Crash Course Biology, we’ll learn about how water’s polarity and hydrogen bonding help it sustain life on a larger scale. We’ll see how some water-based solutions can be acidic or basic, and examine how our bodies maintain the narrow pH range necessary for life.

22. How We See What We Can't See (Microscopes)

There’s an immense world of tiny stuff within us and around us—but how do we know about it? In this episode of Crash Course Biology, we’ll discover how we see what we can’t see, thanks to the help of centuries-old tools and more recent technology. Along the way, we’ll learn about the major types of microscopes and how to use a typical light microscope.

23. A Tour of the Cell

The cell is the basic unit of life, and our understanding of it has advanced as science, and the tools available to scientists, has advanced. In this episode of Crash Course Biology, we’ll take a look at the difference between prokaryotic and eukaryotic cells, take a guided tour of the eukaryotic cell, and learn why most cells are small. We’ll explore the eukaryotic cell’s surprising beginnings through an endosymbiosis that occurred about 1.5 billion years ago.

24. How Does Stuff Get Into Your Cells? (Cell Membranes)

The cell membrane is a protein-studded phospholipid bilayer that not only protects our cells, but also regulates what goes in and out. In this episode of Crash Course Biology, we’ll look at the structure of the bilayer, learn about its discovery, and explore the many ways substances can be transported into and out of cells.

25. How Do Cells Communicate? (Cell Communication)

Even though it might seem like our bodies are on autopilot, there is a whole lot happening inside us to keep things moving. In this episode of Crash Course Biology, we’ll learn that our cells are in constant communication, reminding each other—and themselves—to perform important functions like breathing, walking, or even sleeping.

26. How Do We Get Energy? (Chemical Reactions)

27. How do cells get their energy? (Electron Transport Chain)

28. Photosynthesis: The Original Solar Power

29. Mitosis and the Cell Cycle

30. Why Are All Humans Unique? Meiosis

31. Why Your Cat Looks Like That: Genetics

32. Nature? Nurture? Not so simple: Genetic Traits

33. Our Instruction Manual for Existing: DNA Structure & Replication

34. How mRNA helped save lives: DNA Transcription

35. How RNA gets translated into protein power

36. How Genes Express Themselves

If nearly all your cells have the same DNA, why are muscle cells so different from skin cells? In this episode, we’ll learn how gene expression is regulated in eukaryotes, and how methylating DNA, modifying histones, and messing with translation not only leads to different types of cells, but allows cells to adapt to the world around them.

37. Is drinking milk a Superpower? Genetic Mutations

Science fiction is full of superpowered mutants, but in reality, mutations are much more diverse and complex. Sometimes, they can change someone’s entire body, and other times, we don’t notice them at all! In this episode, we’ll unpack what mutations are, how they work (including substitutions and frameshift mutations), and how scientists are learning to control mutations using tools like CRISPR/Cas9 and gene therapy.

38. We’re full of bacteria!

Bacteria often get a bad rap, but they’re some of our best partners in science and medicine! In this episode, we’ll explore what bacteria are doing with their DNA — including how they can trade it around. We’ll learn about chromosomes and plasmids, gene expression and recombinant DNA, and how E. coli are used to make insulin.

39. How Do Vaccines Work?: Viruses & Vaccines

From the flu to COVID-19, viruses are a major threat in our everyday lives. In today’s episode of Crash Course Biology, we’ll learn why viruses are like genes in a box, and how they invade and spread between cells. We’ll also discover how vaccines and medicines help our bodies fight back.

40. Algorithms Aren’t Just for TikTok: Bioinformatics

On its own, a huge DNA sequence is a meaningless pile of data — so, how do biologists figure out what it means? They turn to the power of bioinformatics! In this episode, we’ll learn what bioinformatics is, how it works, and how scientists have used it to better understand everything from evolution to a viral epidemic.

41. Why We Aren’t Just One Big Cell: Multicellular Function

There are countless types of plants and animals on Earth, but how do they work? In this episode of Crash Course Biology, we’ll take a bird’s eye view of how multicellular life functions, including how it’s organized, how it regulates itself to maintain homeostasis, and the big question: Why are these living things so wildly complex?

42. Plants Are Hardcore: Plant Anatomy & Physiology

Plants may not seem like they’re doing much, but if you look closer, you’ll find a whole world just lurking beyond the surface. We’re talking chemical defenses, highways, and even ways to change the weather. In this episode, we’ll learn how plants get resources, get rid of waste, stay defended, govern themselves, and much more.

43. The Poop Episode: How Animals Turn Resources Into Waste

Yep, this is the poop episode. Getting resources and getting rid of waste is so important, we have three whole systems dedicated to it! In this episode, we’ll learn how the respiratory system, digestive system, and urinary system work, and visit some other animals that process their resources in completely different (and sometimes totally wild) ways.

44. Why You’re More Than Goo: Animal Infrastructure

When you think about the body’s infrastructure, you probably think of bones. But what about the heart, the blood vessels, and the lymphatic system? In this episode of Crash Course Biology, we’ll tour the cardiovascular, lymphatic, and musculoskeletal systems, learning how all of them keep a vertebrate’s inner workings connected, powered up, and ready to move.

45. How Skin, Snot, and Cells Keep Us Healthy: Animal Defense Systems

The world is full of microbes and viruses that can get us sick, but we’ve got an Avengers-style defense system ready to take them on. In this episode of Crash Course Biology, we’ll learn about an animal’s immune system, from their skin to inflammatory responses, to the adaptive immune system and all the special cells and antibodies that come with it.

46. What REALLY Happens When You Step on a Lego: Nervous & Endocrine Systems

If cells and organs never talked to each other, an animal would fall apart faster than a boy band after the popular one goes solo. Thankfully, that’s where the nervous and endocrine systems come in! In this episode of Crash Course Biology, we’ll learn how they use neurons, hormones, and more to keep animals’ bodies coordinated.

47. How Animals Do It: Sexual & Asexual Reproduction

When it comes to animal reproduction, there’s no one-size-fits-all strategy. Some animals need a mate, others don’t, and for some, it depends! In this episode, we’ll learn about sexual and asexual reproduction, internal and external fertilization, and all the ways that life, uh… finds a way.

48. Gender, Sex, & Sexuality: What’s the Difference?

We tend to think life fits in two tidy categories: male or female, XX or XY. But it’s so much more diverse and complicated! In this episode of Crash Course Biology, we’ll discover sex and sexuality as a continuum across life. We’ll learn why humans are the only species with gender, and why same-sex mating is more common than you might think.

49. Why This Toad is Bad at Jumping, and Other Mysterious Animal Behavior

Why do animals do what they do? It’s a huge question, and in this episode, we’ll learn how scientists break it down. We’ll talk about the proximate and ultimate studies they use to understand animal behavior, and some of what they’ve learned along the way — including how much decision-making other animals are really doing.

50. The Dr. Sammy Show

Biology connects all of life—all of YOUR life. In the final episode of Crash Course Biology, Dr. Sammy is taking your questions. No matter how big, small, or personal, biology is in them all! He’ll show us how biology can help us solve problems and understand everyday life.